Title | High-fructose corn syrup enhances intestinal tumor growth in mice. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang S-K, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, H Lekaye C, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC, Yun J |
Journal | Science |
Volume | 363 |
Issue | 6433 |
Pagination | 1345-1349 |
Date Published | 2019 03 22 |
ISSN | 1095-9203 |
Keywords | Adenomatous Polyposis Coli Protein, Animals, Carcinogenesis, Diet, High Fructose Corn Syrup, Intestinal Neoplasms, Mice, Mice, Mutant Strains, Neoplasm Grading, Tumor Burden |
Abstract | Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis. |
DOI | 10.1126/science.aat8515 |
Alternate Journal | Science |
PubMed ID | 30898933 |
PubMed Central ID | PMC6487857 |
Grant List | K22 CA216036 / CA / NCI NIH HHS / United States T32 AI007640 / AI / NIAID NIH HHS / United States R01 NS093872 / NS / NINDS NIH HHS / United States K08 CA230318 / CA / NCI NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States R35 CA197588 / CA / NCI NIH HHS / United States P01 HD067244 / HD / NICHD NIH HHS / United States |