Publications

Pandey S, Singh A, Yang G, d'Andrea FB, Jiang X, Hartman TE, Mosior JW, Bourland R, Gold B, Roberts J et al..  2021.  Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis.. Microbiol Spectr. 9(2):e0092821.

Taylor SR.  2021.  Dietary fructose improves intestinal cell survival and nutrient absorption.. Nature. 597:263-267.

Liang RJ, Taylor S, Nahiyaan N, Song J, Murphy CJ, Dantas E, Cheng S, Hsu T-W, Ramsamooj S, Grover R et al..  2021.  GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.. Cancer Metab. 9(1):12.

Gouzy A, Healy C, Black KA, Rhee KY, Ehrt, Sabine.  2021.  Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity.. Proc Natl Acad Sci U S A. 118(32)

McElvaine AT, Hawkins-Salsbury JA, Arora VM, Gladwin MT, Goldenring JR, Huston DP, Krakow D, Rhee K, Solway J, Steinman RA et al..  2021.  Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative.. J Clin Invest. 131(10)

Black KA.  2021.  Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. Journal of Experimental Medicine. 218(7):e20191957.

Planck KA, Rhee K.  2021.  Metabolomics of Mycobacterium tuberculosis.. Methods Mol Biol. 2314:579-593.

Schrader SM, Botella H, Jansen R, Ehrt, Sabine, Rhee K, Nathan C, Vaubourgeix J.  2021.  Multiform antimicrobial resistance from a metabolic mutation.. Sci Adv. 7(35)

Beites T, Jansen RS, Wang R, Jinich A, Rhee KY, Schnappinger D, Ehrt, Sabine.  2021.  Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.. Nat Commun. 12(1):6593.

Ma S, Morrison R, Hobbs SJ, Soni V, Farrow-Johnson J, Frando A, Fleck N, Grundner C, Rhee KY, Rustad TR et al..  2021.  Transcriptional regulator-induced phenotype screen reveals drug potentiators in Mycobacterium tuberculosis.. Nat Microbiol. 6(1):44-50.

Aldridge BB, Barros-Aguirre D, Barry CE, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu X-J, Cooper CB, Dartois V et al..  2021.  The Tuberculosis Drug Accelerator at year 10: what have we learned? Nat Med. 27(8):1333-1337.

Ginn J, Jiang X, Sun S, Michino M, Huggins DJ, Mbambo Z, Jansen R, Rhee KY, Arango N, Lima CD et al..  2021.  Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.. ACS Infect Dis. 7(2):435-444.

Jansen RS, Mandyoli L, Hughes R, Wakabayashi S, Pinkham JT, Selbach B, Guinn KM, Rubin EJ, Sacchettini, James C, Rhee KY.  2020.  Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.. Nat Commun. 11(1):1960.

Zaveri A, Wang R, Botella L, Sharma R, Zhu L, Wallach JB, Song N, Jansen RS, Rhee KY, Ehrt, Sabine et al..  2020.  Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.. Mol Microbiol. 114(4):641-652.

Krisko TI, Nicholls HT, Bare CJ, Holman CD, Putzel GG, Jansen RS, Sun N, Rhee KY, Banks AS, Cohen DE.  2020.  Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice.. Cell Metab. 31(3):592-604.e9.

Szeri F, Lundkvist S, Donnelly S, Engelke UFH, Rhee K, Williams CJ, Sundberg JP, Wevers RA, Tomlinson RE, Jansen RS et al..  2020.  The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.. PLoS Genet. 16(7):e1008884.

Hards K, Adolph C, Harold LK, McNeil MB, Cheung C-Y, Jinich A, Rhee KY, Cook GM.  2020.  Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents.. Prog Biophys Mol Biol. 152:35-44.

Whitaker M, Ruecker N, Hartman T, Klevorn T, Andres J, Kim J, Rhee K, Ehrt, Sabine.  2020.  Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity.. J Bacteriol.

Xia Q, Lee MHee, Walsh KF, McAulay K, Bean JM, Fitzgerald DW, Dupnik KM, Johnson WD, Pape JW, Rhee KY et al..  2020.  Urinary biomarkers of mycobacterial load and treatment response in pulmonary tuberculosis.. JCI Insight. 5(18)

Patel V, Black KA, Rhee KY, Helmann JD.  2019.  Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis.. PLoS Genet. 15(10):e1008434.

Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang S-K, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K et al..  2019.  High-fructose corn syrup enhances intestinal tumor growth in mice.. Science. 363(6433):1345-1349.

Daou N, Wang Y, Levdikov VM, Nandakumar M, Livny J, Bouillaut L, Blagova E, Zhang K, Belitsky BR, Rhee K et al..  2019.  Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027.. PLoS One. 14(1):e0206896.

Wang Z, Soni V, Marriner G, Kaneko T, Boshoff HIM, Barry CE, Rhee KY.  2019.  Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.. Proc Natl Acad Sci U S A. 116(39):19646-19651.

Lu X, Williams Z, Hards K, Tang J, Cheung C-Y, Aung HLin, Wang B, Liu Z, Hu X, Lenaerts A et al..  2019.  Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.. ACS Infect Dis. 5(2):239-249.

Hodakoski C, Hopkins BD, Zhang G, Su T, Cheng Z, Morris R, Rhee KY, Goncalves MD, Cantley LC.  2019.  Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer.. Cancers (Basel). 11(1)