Publications

Hartman TE, Rhee KY.  2015.  Microbial Metabolomics: Fifty Shades of Metabolism.. ACS Infect Dis. 1(1):73-5.

Kardon JR, Yien YY, Huston NC, Branco DS, Hildick-Smith GJ, Rhee KY, Paw BH, Baker TA.  2015.  Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.. Cell. 161(4):858-67.

Ehrt, Sabine, Rhee K, Schnappinger D.  2015.  Mycobacterial genes essential for the pathogen's survival in the host.. Immunol Rev. 264(1):319-26.

Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D et al..  2015.  Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.. J Med Chem. 58(18):7349-7369.

Chakraborty S, Rhee KY.  2015.  Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.. Cold Spring Harb Perspect Med. 5(8):a021147.

Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt, Sabine.  2015.  Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.

Eoh H, Rhee KY.  2014.  Allostery and compartmentalization: old but not forgotten.. Curr Opin Microbiol. 18:23-9.

Nixon MR, Saionz KW, Koo M-S, Szymonifka MJ, Jung H, Roberts JP, Nandakumar M, Kumar A, Liao R, Rustad T et al..  2014.  Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.. Chem Biol. 21(7):819-30.

Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrè D, Rhee KY, Sonenshein AL.  2014.  Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.. Proc Natl Acad Sci U S A. 111(22):8227-32.

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt, Sabine.  2014.  Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.. PLoS Pathog. 10(5):e1004144.

Alexander EL, Gardete S, Bar HY, Wells MT, Tomasz A, Rhee KY.  2014.  Intermediate-type vancomycin resistance (VISA) in genetically-distinct Staphylococcus aureus isolates is linked to specific, reversible metabolic alterations.. PLoS One. 9(5):e97137.

Nandakumar M, Nathan C, Rhee KY.  2014.  Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.. Nat Commun. 5:4306.

Baughn AD, Rhee KY.  2014.  Metabolomics of Central Carbon Metabolism in Mycobacterium tuberculosis.. Microbiol Spectr. 2(3)

Eoh H, Rhee KY.  2014.  Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids.. Proc Natl Acad Sci U S A. 111(13):4976-81.

Aldridge BB, Rhee KY.  2014.  Microbial metabolomics: innovation, application, insight.. Curr Opin Microbiol. 19:90-96.

Patel SJ, Oliveira AP, Zhou JJulia, Alba L, E Furuya Y, Weisenberg SA, Jia H, Clock SA, Kubin CJ, Jenkins SG et al..  2014.  Risk factors and outcomes of infections caused by extremely drug-resistant gram-negative bacilli in patients hospitalized in intensive care units.. Am J Infect Control. 42(6):626-31.

Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt, Sabine.  2014.  Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.. mBio. 5(2):e00085.

Zhou JJulia, Patel SJ, Jia H, Weisenberg SA, E Furuya Y, Kubin CJ, Alba L, Rhee K, Saiman L.  2013.  Clinicians' knowledge, attitudes, and practices regarding infections with multidrug-resistant gram-negative bacilli in intensive care units.. Infect Control Hosp Epidemiol. 34(3):274-83.

Marrero J, Trujillo C, Rhee KY, Ehrt, Sabine.  2013.  Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.. PLoS Pathog. 9(1):e1003116.

Rhee K.  2013.  Minding the gaps: metabolomics mends functional genomics.. EMBO Rep. 14(11):949-50.

Eoh H, Rhee KY.  2013.  Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 110(16):6554-9.

Ehrt, Sabine, Rhee K.  2013.  Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.. Curr Top Microbiol Immunol. 374:163-88.

Chakraborty S, Gruber T, Barry CE, Boshoff HI, Rhee KY.  2013.  Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.. Science. 339(6115):88-91.

Weisenberg SA, Mediavilla JR, Chen L, Alexander EL, Rhee KY, Kreiswirth BN, Jenkins SG.  2012.  Extended spectrum beta-lactamase-producing Enterobacteriaceae in international travelers and non-travelers in New York City.. PLoS One. 7(9):e45141.

Lakshmanan V, Rhee KY, Wang W, Yu Y, Khafizov K, Fiser A, Wu P, Ndir O, Mboup S, Ndiaye D et al..  2012.  Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum.. J Infect Dis. 206(2):238-48.