Publications

Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini, James C et al..  2018.  Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.. ACS Infect Dis. 4(5):771-787.

Isa F, Collins S, Lee MHee, Decome D, Dorvil N, Joseph P, Smith L, Salerno S, Wells MT, Fischer S et al..  2018.  Mass Spectrometric Identification of Urinary Biomarkers of Pulmonary Tuberculosis.. EBioMedicine. 31:157-165.

Ehrt, Sabine, Schnappinger D, Rhee KY.  2018.  Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.. Nat Rev Microbiol. 16(8):496-507.

Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri L-P, Moody CStuver, Zeng J, Prisic S et al..  2018.  Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface.. mBio. 9(2)

Kumar P, Capodagli GC, Awasthi D, Shrestha R, Maharaja K, Sukheja P, Li S-G, Inoyama D, Zimmerman M, Liang HPin Ho et al..  2018.  Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.. mBio. 9(6)

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al..  2018.  Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

Chen C, Gardete S, Jansen RSander, Shetty A, Dick T, Rhee KY, Dartois V.  2018.  Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. 62(5)

Lazar N, Fay A, Nandakumar M, Boyle KE, Xavier J, Rhee K, Glickman MS.  2017.  Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal.. Mol Microbiol. 106(6):1018-1031.

Irnov I, Wang Z, Jannetty ND, Bustamante JA, Rhee KY, Jacobs-Wagner C.  2017.  Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate.. PLoS Genet. 13(8):e1006978.

Jansen RS, Rhee KY.  2017.  Emerging Approaches to Tuberculosis Drug Development: At Home in the Metabolome.. Trends Pharmacol Sci. 38(4):393-405.

Park Y, Pacitto A, Bayliss T, Cleghorn LAT, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M et al..  2017.  Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.. ACS Infect Dis. 3(1):18-33.

Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt, Sabine.  2017.  Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.. Cell Chem Biol. 24(3):306-315.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt, Sabine.  2017.  Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

Eoh H, Wang Z, Layre E, Rath P, Morris R, D Moody B, Rhee KY.  2017.  Metabolic anticipation in Mycobacterium tuberculosis.. Nat Microbiol. 2:17084.

Hartman TE, Wang Z, Jansen RS, Gardete S, Rhee KY.  2017.  Metabolic Perspectives on Persistence.. Microbiol Spectr. 5(1)

Boyle KE, Monaco HT, Deforet M, Yan J, Wang Z, Rhee K, Xavier JB.  2017.  Metabolism and the Evolution of Social Behavior.. Mol Biol Evol. 34(9):2367-2379.

Samuels DJ, Wang Z, Rhee KY, Brinsmade SR.  2017.  A Tandem Liquid Chromatography-Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus.. J Vis Exp. (121)

Noy T, Vergnolle O, Hartman TE, Rhee KY, Jacobs WR, Berney M, Blanchard JS.  2016.  Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis.. J Biol Chem. 291(13):7060-9.

Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M et al..  2016.  Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.. Cell Rep. 14(3):572-585.

Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J et al..  2016.  N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 113(31):E4523-30.

Waters NR, Samuels DJ, Behera RK, Livny J, Rhee KY, Sadykov MR, Brinsmade SR.  2016.  A spectrum of CodY activities drives metabolic reorganization and virulence gene expression in Staphylococcus aureus.. Mol Microbiol. 101(3):495-514.

Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, Nathan C.  2015.  Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.. Tuberculosis (Edinb). 95(6):689-694.

Maksymiuk C, Balakrishnan A, Bryk R, Rhee KY, Nathan CF.  2015.  E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.. Proc Natl Acad Sci U S A. 112(43):E5834-43.

Li S-G, Vilchèze C, Chakraborty S, Wang X, Kim H, Anisetti M, Ekins S, Rhee KY, Jacobs WR, Freundlich JS.  2015.  Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.. Tetrahedron Lett. 56(23):3246-3250.

Nandakumar M, Prosser GA, de Carvalho LPedro S, Rhee K.  2015.  Metabolomics of Mycobacterium tuberculosis.. Methods Mol Biol. 1285:105-15.