Submitted by san2025 on January 12, 2022 - 9:26pm
Title | Metabolic anticipation in Mycobacterium tuberculosis. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Eoh H, Wang Z, Layre E, Rath P, Morris R, D Moody B, Rhee KY |
Journal | Nat Microbiol |
Volume | 2 |
Pagination | 17084 |
Date Published | 2017 May 22 |
ISSN | 2058-5276 |
Keywords | Adaptation, Physiological, Cell Cycle, Cell Wall, Hypoxia, Mycobacterium tuberculosis, Mycolic Acids, Peptidoglycan |
Abstract | Humans serve as both host and reservoir for Mycobacterium tuberculosis, making tuberculosis a theoretically eradicable disease. How M. tuberculosis alternates between host-imposed quiescence and sporadic bouts of replication to complete its life cycle, however, remains unknown. Here, we identify a metabolic adaptation that is triggered upon entry into hypoxia-induced quiescence but facilitates subsequent cell cycle re-entry. Catabolic remodelling of the cell surface trehalose mycolates of M. tuberculosis specifically generates metabolic intermediates reserved for re-initiation of peptidoglycan biosynthesis. These adaptations reveal a metabolic network with the regulatory capacity to mount an anticipatory response. |
DOI | 10.1038/nmicrobiol.2017.84 |
Alternate Journal | Nat Microbiol |
PubMed ID | 28530656 |
PubMed Central ID | PMC5540153 |
Grant List | T32 AI007640 / AI / NIAID NIH HHS / United States U19 AI111143 / AI / NIAID NIH HHS / United States |