Publications

Gouzy A, Healy C, Black KA, Rhee KY, Ehrt, Sabine.  2021.  Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity.. Proc Natl Acad Sci U S A. 118(32)

Black KA.  2021.  Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. Journal of Experimental Medicine. 218(7):e20191957.

Schrader SM, Botella H, Jansen R, Ehrt, Sabine, Rhee K, Nathan C, Vaubourgeix J.  2021.  Multiform antimicrobial resistance from a metabolic mutation.. Sci Adv. 7(35)

Beites T, Jansen RS, Wang R, Jinich A, Rhee KY, Schnappinger D, Ehrt, Sabine.  2021.  Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.. Nat Commun. 12(1):6593.

Zaveri A, Wang R, Botella L, Sharma R, Zhu L, Wallach JB, Song N, Jansen RS, Rhee KY, Ehrt, Sabine et al..  2020.  Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.. Mol Microbiol. 114(4):641-652.

Whitaker M, Ruecker N, Hartman T, Klevorn T, Andres J, Kim J, Rhee K, Ehrt, Sabine.  2020.  Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity.. J Bacteriol.

Ehrt, Sabine, Schnappinger D, Rhee KY.  2018.  Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.. Nat Rev Microbiol. 16(8):496-507.

Tiwari D, Park SWoong, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HPin, Engelhart CA et al..  2018.  Targeting protein biotinylation enhances tuberculosis chemotherapy.. Sci Transl Med. 10(438)

Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt, Sabine.  2017.  Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.. Cell Chem Biol. 24(3):306-315.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt, Sabine.  2017.  Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

Ehrt, Sabine, Rhee K, Schnappinger D.  2015.  Mycobacterial genes essential for the pathogen's survival in the host.. Immunol Rev. 264(1):319-26.

Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LPedro Sori, Rhee K, Ehrt, Sabine.  2015.  Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. Nat Commun. 6:7912.

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt, Sabine.  2014.  Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.. PLoS Pathog. 10(5):e1004144.

Trujillo C, Blumenthal A, Marrero J, Rhee KY, Schnappinger D, Ehrt, Sabine.  2014.  Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.. mBio. 5(2):e00085.

Marrero J, Trujillo C, Rhee KY, Ehrt, Sabine.  2013.  Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.. PLoS Pathog. 9(1):e1003116.

Ehrt, Sabine, Rhee K.  2013.  Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.. Curr Top Microbiol Immunol. 374:163-88.

Rhee KY, de Carvalho LPedro Sori, Bryk R, Ehrt, Sabine, Marrero J, Park SWoong, Schnappinger D, Venugopal A, Nathan C.  2011.  Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.. Trends Microbiol. 19(7):307-14.

Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt, Sabine, Nathan C.  2011.  Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.. Cell Host Microbe. 9(1):21-31.

Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt, Sabine.  2010.  Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.. Proc Natl Acad Sci U S A. 107(21):9819-24.

de Carvalho LPedro S, Fischer SM, Marrero J, Nathan C, Ehrt, Sabine, Rhee KY.  2010.  Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.. Chem Biol. 17(10):1122-31.

Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S et al..  2008.  Selective killing of nonreplicating mycobacteria.. Cell Host Microbe. 3(3):137-45.