Publications

Rhee KY, Erdjument-Bromage H, Tempst P, Nathan CF.  2005.  S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.. Proc Natl Acad Sci U S A. 102(2):467-72.

Rhee KY, Soave R, Maltz C.  2004.  Methicillin-resistant Staphylococcus aureus as a cause of antibiotic-associated diarrhea.. J Clin Gastroenterol. 38(3):299-300.

Rhee KY, Gardiner DF, Charles M.  2005.  Decreasing in vitro susceptibility of clinical Staphylococcus aureus isolates to vancomycin at the New York Hospital: quantitative testing redux.. Clin Infect Dis. 40(11):1705-6.

Rhee KY, Parekh BS, Hatfield GW.  1996.  Leucine-responsive regulatory protein-DNA interactions in the leader region of the ilvGMEDA operon of Escherichia coli.. J Biol Chem. 271(43):26499-507.

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt, Sabine.  2014.  Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.. PLoS Pathog. 10(5):e1004144.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt, Sabine.  2017.  Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

Planck KA, Rhee K.  2021.  Metabolomics of Mycobacterium tuberculosis.. Methods Mol Biol. 2314:579-593.

Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WYee, Patel V, Beer D, Walker JR, Duraiswamy J et al..  2010.  A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.. Nat Commun. 1:57.

Patel SJ, Oliveira AP, Zhou JJulia, Alba L, E Furuya Y, Weisenberg SA, Jia H, Clock SA, Kubin CJ, Jenkins SG et al..  2014.  Risk factors and outcomes of infections caused by extremely drug-resistant gram-negative bacilli in patients hospitalized in intensive care units.. Am J Infect Control. 42(6):626-31.

Patel V, Black KA, Rhee KY, Helmann JD.  2019.  Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis.. PLoS Genet. 15(10):e1008434.

Park Y, Pacitto A, Bayliss T, Cleghorn LAT, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M et al..  2017.  Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.. ACS Infect Dis. 3(1):18-33.

Pandey S, Singh A, Yang G, d'Andrea FB, Jiang X, Hartman TE, Mosior JW, Bourland R, Gold B, Roberts J et al..  2021.  Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis.. Microbiol Spectr. 9(2):e0092821.

Osborne TF, Bennett M, Rhee K.  1992.  Red 25, a protein that binds specifically to the sterol regulatory region in the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.. J Biol Chem. 267(26):18973-82.

Noy T, Vergnolle O, Hartman TE, Rhee KY, Jacobs WR, Berney M, Blanchard JS.  2016.  Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis.. J Biol Chem. 291(13):7060-9.

Nixon MR, Saionz KW, Koo M-S, Szymonifka MJ, Jung H, Roberts JP, Nandakumar M, Kumar A, Liao R, Rustad T et al..  2014.  Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.. Chem Biol. 21(7):819-30.

Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini, James C et al..  2018.  Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.. ACS Infect Dis. 4(5):771-787.

Nandakumar M, Prosser GA, de Carvalho LPedro S, Rhee K.  2015.  Metabolomics of Mycobacterium tuberculosis.. Methods Mol Biol. 1285:105-15.

Nandakumar M, Nathan C, Rhee KY.  2014.  Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.. Nat Commun. 5:4306.

McElvaine AT, Hawkins-Salsbury JA, Arora VM, Gladwin MT, Goldenring JR, Huston DP, Krakow D, Rhee K, Solway J, Steinman RA et al..  2021.  Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative.. J Clin Invest. 131(10)

Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt, Sabine.  2010.  Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.. Proc Natl Acad Sci U S A. 107(21):9819-24.

Marrero J, Trujillo C, Rhee KY, Ehrt, Sabine.  2013.  Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.. PLoS Pathog. 9(1):e1003116.

Maksymiuk C, Balakrishnan A, Bryk R, Rhee KY, Nathan CF.  2015.  E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.. Proc Natl Acad Sci U S A. 112(43):E5834-43.

Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, Nathan C.  2015.  Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.. Tuberculosis (Edinb). 95(6):689-694.

Ma S, Morrison R, Hobbs SJ, Soni V, Farrow-Johnson J, Frando A, Fleck N, Grundner C, Rhee KY, Rustad TR et al..  2021.  Transcriptional regulator-induced phenotype screen reveals drug potentiators in Mycobacterium tuberculosis.. Nat Microbiol. 6(1):44-50.

Lu X, Williams Z, Hards K, Tang J, Cheung C-Y, Aung HLin, Wang B, Liu Z, Hu X, Lenaerts A et al..  2019.  Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.. ACS Infect Dis. 5(2):239-249.