Publications

Eoh H, Wang Z, Layre E, Rath P, Morris R, D Moody B, Rhee KY.  2017.  Metabolic anticipation in Mycobacterium tuberculosis.. Nat Microbiol. 2:17084.

Eoh H, Rhee KY.  2014.  Allostery and compartmentalization: old but not forgotten.. Curr Opin Microbiol. 18:23-9.

Eoh H, Rhee KY.  2014.  Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids.. Proc Natl Acad Sci U S A. 111(13):4976-81.

Ehrt, Sabine, Schnappinger D, Rhee KY.  2018.  Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.. Nat Rev Microbiol. 16(8):496-507.

Ehrt, Sabine, Rhee K, Schnappinger D.  2015.  Mycobacterial genes essential for the pathogen's survival in the host.. Immunol Rev. 264(1):319-26.

Ehrt, Sabine, Rhee K.  2013.  Mycobacterium tuberculosis metabolism and host interaction: mysteries and paradoxes.. Curr Top Microbiol Immunol. 374:163-88.

de Carvalho LPedro S, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C, Rhee KY.  2010.  Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.. Chem Biol. 17(4):323-32.

de Carvalho LPedro S, Darby CM, Rhee KY, Nathan C.  2011.  Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis.. ACS Med Chem Lett. 2(11):849-854.

de Carvalho LPedro S, Ling Y, Shen C, J Warren D, Rhee KY.  2011.  On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis.. Arch Biochem Biophys. 509(1):90-9.

de Carvalho LPedro S, Fischer SM, Marrero J, Nathan C, Ehrt, Sabine, Rhee KY.  2010.  Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.. Chem Biol. 17(10):1122-31.

Daou N, Wang Y, Levdikov VM, Nandakumar M, Livny J, Bouillaut L, Blagova E, Zhang K, Belitsky BR, Rhee K et al..  2019.  Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027.. PLoS One. 14(1):e0206896.

Chen C, Gardete S, Jansen RSander, Shetty A, Dick T, Rhee KY, Dartois V.  2018.  Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis.. Antimicrob Agents Chemother. 62(5)

Charles M, Rhee KY.  2004.  Priorities for the treatment of latent tuberculosis.. N Engl J Med. 351(8):832-4;authorreply832-4.

Chakraborty S, Gruber T, Barry CE, Boshoff HI, Rhee KY.  2013.  Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.. Science. 339(6115):88-91.

Chakraborty S, Rhee KY.  2015.  Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.. Cold Spring Harb Perspect Med. 5(8):a021147.

Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri L-P, Moody CStuver, Zeng J, Prisic S et al..  2018.  Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface.. mBio. 9(2)

Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S et al..  2008.  Selective killing of nonreplicating mycobacteria.. Cell Host Microbe. 3(3):137-45.

Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrè D, Rhee KY, Sonenshein AL.  2014.  Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.. Proc Natl Acad Sci U S A. 111(22):8227-32.

Boyle KE, Monaco HT, Deforet M, Yan J, Wang Z, Rhee K, Xavier JB.  2017.  Metabolism and the Evolution of Social Behavior.. Mol Biol Evol. 34(9):2367-2379.

Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D et al..  2015.  Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.. J Med Chem. 58(18):7349-7369.

Blumenthal A, Isovski F, Rhee KY.  2009.  Tuberculosis and host metabolism: ancient associations, fresh insights.. Transl Res. 154(1):7-14.

Black KA.  2021.  Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. Journal of Experimental Medicine. 218(7):e20191957.

Beites T, Jansen RS, Wang R, Jinich A, Rhee KY, Schnappinger D, Ehrt, Sabine.  2021.  Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.. Nat Commun. 12(1):6593.

Baughn AD, Rhee KY.  2014.  Metabolomics of Central Carbon Metabolism in Mycobacterium tuberculosis.. Microbiol Spectr. 2(3)

Alexander EL, Gardete S, Bar HY, Wells MT, Tomasz A, Rhee KY.  2014.  Intermediate-type vancomycin resistance (VISA) in genetically-distinct Staphylococcus aureus isolates is linked to specific, reversible metabolic alterations.. PLoS One. 9(5):e97137.