Publications

Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M et al..  2016.  Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.. Cell Rep. 14(3):572-585.

Park Y, Pacitto A, Bayliss T, Cleghorn LAT, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M et al..  2017.  Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.. ACS Infect Dis. 3(1):18-33.

Li S-G, Vilchèze C, Chakraborty S, Wang X, Kim H, Anisetti M, Ekins S, Rhee KY, Jacobs WR, Freundlich JS.  2015.  Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.. Tetrahedron Lett. 56(23):3246-3250.

Lemos MP, Rhee KY, McKinney JD.  2011.  Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression.. J Immunol. 187(7):3776-84.

Weisenberg SA, Mediavilla JR, Chen L, Alexander EL, Rhee KY, Kreiswirth BN, Jenkins SG.  2012.  Extended spectrum beta-lactamase-producing Enterobacteriaceae in international travelers and non-travelers in New York City.. PLoS One. 7(9):e45141.

Nixon MR, Saionz KW, Koo M-S, Szymonifka MJ, Jung H, Roberts JP, Nandakumar M, Kumar A, Liao R, Rustad T et al..  2014.  Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.. Chem Biol. 21(7):819-30.

Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt, Sabine.  2017.  Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.. Cell Chem Biol. 24(3):306-315.

Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt, Sabine.  2010.  Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.. Proc Natl Acad Sci U S A. 107(21):9819-24.

Marrero J, Trujillo C, Rhee KY, Ehrt, Sabine.  2013.  Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.. PLoS Pathog. 9(1):e1003116.

Liang RJ, Taylor S, Nahiyaan N, Song J, Murphy CJ, Dantas E, Cheng S, Hsu T-W, Ramsamooj S, Grover R et al..  2021.  GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.. Cancer Metab. 9(1):12.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt, Sabine.  2017.  Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 114(11):E2225-E2232.

Gouzy A, Healy C, Black KA, Rhee KY, Ehrt, Sabine.  2021.  Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity.. Proc Natl Acad Sci U S A. 118(32)

Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrè D, Rhee KY, Sonenshein AL.  2014.  Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY.. Proc Natl Acad Sci U S A. 111(22):8227-32.

Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang S-K, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K et al..  2019.  High-fructose corn syrup enhances intestinal tumor growth in mice.. Science. 363(6433):1345-1349.

Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini, James C et al..  2018.  Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.. ACS Infect Dis. 4(5):771-787.

Daou N, Wang Y, Levdikov VM, Nandakumar M, Livny J, Bouillaut L, Blagova E, Zhang K, Belitsky BR, Rhee K et al..  2019.  Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027.. PLoS One. 14(1):e0206896.

Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt, Sabine.  2014.  Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.. PLoS Pathog. 10(5):e1004144.

McElvaine AT, Hawkins-Salsbury JA, Arora VM, Gladwin MT, Goldenring JR, Huston DP, Krakow D, Rhee K, Solway J, Steinman RA et al..  2021.  Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative.. J Clin Invest. 131(10)

Alexander EL, Gardete S, Bar HY, Wells MT, Tomasz A, Rhee KY.  2014.  Intermediate-type vancomycin resistance (VISA) in genetically-distinct Staphylococcus aureus isolates is linked to specific, reversible metabolic alterations.. PLoS One. 9(5):e97137.

Nandakumar M, Nathan C, Rhee KY.  2014.  Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.. Nat Commun. 5:4306.

Rhee KY, Parekh BS, Hatfield GW.  1996.  Leucine-responsive regulatory protein-DNA interactions in the leader region of the ilvGMEDA operon of Escherichia coli.. J Biol Chem. 271(43):26499-507.

Isa F, Collins S, Lee MHee, Decome D, Dorvil N, Joseph P, Smith L, Salerno S, Wells MT, Fischer S et al..  2018.  Mass Spectrometric Identification of Urinary Biomarkers of Pulmonary Tuberculosis.. EBioMedicine. 31:157-165.

Szeri F, Lundkvist S, Donnelly S, Engelke UFH, Rhee K, Williams CJ, Sundberg JP, Wevers RA, Tomlinson RE, Jansen RS et al..  2020.  The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.. PLoS Genet. 16(7):e1008884.

Eoh H, Wang Z, Layre E, Rath P, Morris R, D Moody B, Rhee KY.  2017.  Metabolic anticipation in Mycobacterium tuberculosis.. Nat Microbiol. 2:17084.

Black KA.  2021.  Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. Journal of Experimental Medicine. 218(7):e20191957.